Cthrc1 gene

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August undefined, 2024

WebApr 21, 2024 · One subpopulation, characterized by expression of Cthrc1 (collagen triple helix repeat containing 1), emerges in fibrotic lungs and expresses the highest levels of collagens. ... Gene expression ... WebOct 8, 2012 · Generation of Cthrc1 null mice. (A) Cthrc1 gene targeting schematic showing replacement of exons 2-4 with a PGK-neo cassette. (B) Embryonic stem cell targeting with Southern blot analysis of ...

Cthrc1, a Novel Circulating Hormone Regulating Metabolism

WebOct 8, 2012 · Background We discovered the gene Collagen Triple Helix Repeat Containing 1 (Cthrc1) and reported its developmental expression and induction in adventitial cells of injured arteries and dermal cells of skin wounds. The role of Cthrc1 in normal adult tissues has not yet been determined. Methodology/Principal Findings We … WebJan 29, 2013 · Colorectal cancer (CRC) patients with peritoneal carcinomatosis (PC) have a poor prognosis. Over the last decade, increasing evidence has suggested that the Collagen Triple Helix Repeat Containing 1 (CTHRC1) gene is involved in cancer progression and invasion. In this study, we investigated the expression of CTHRC1 in CRC and its … slowing down in music term

Parallel single-cell and bulk transcriptome analyses reveal key ...

WebOct 6, 2024 · According to the previous reports, the collagen triple helix repeat containing 1 (CTHRC1) causes tumorigenesis by modulating the tumor microenvironment, however, the evidence is limited to a few human cancer subtypes. ... (GEO) based datasets. During the analysis, we simply queue the CTHRC1 gene in these databases to acquire the KM … WebAug 7, 2024 · We reveal gene expression signatures that demarcate fibroblasts from mural cells and provide molecular signatures for cell subtype identification. ... C1qtnf3, and Cthrc1) their distribution in ... WebSep 9, 2008 · Methodology/Principal Findings. We identified collagen triple helix repeat containing-1 (Cthrc1) as a downstream target of bone morphogenetic protein-2 (BMP2) in osteochondroprogenitor-like cells by PCR-based suppression subtractive hybridization followed by differential hybridization, and found that Cthrc1 was expressed in bone … slowing down hand gesture

Single-Cell RNA Sequencing Analysis Reveals a Crucial …

Cthrc1 Is a Positive Regulator of Osteoblastic Bone Formation

WebFeb 22, 2007 · We identified collagen triple helix repeat containing-1 (Cthrc1) as a novel gene expressed in the adventitia and neointima on arterial injury and found that it functionally increases cell migration while reducing collagen deposition. To address the in vivo role of Cthrc1, we generated transgenic mouse lines that constitutively overexpress … WebAug 30, 2024 · Gene ID: 68588, updated on 30-Aug-2024. Summary Other designations. collagen triple helix repeat-containing protein 1. GeneRIFs: Gene References Into … software mbWebSep 21, 2011 · Orloff et al. (2011) identified a germline 131A-C transversion in exon 1 of the CTHRC1 gene, resulting in a gln44-to-pro (Q44P) substitution, in 1 (1.1%) of 116 patients of European descent with Barrett esophagus and/or esophageal adenocarcinoma ().The mutation was not found in 125 controls. The same mutation was found in 1 (1.7%) of 58 … slowing down heart rate

"Webby Gene › by Protein › CTHRC1 Antibodies; CTHRC1 Antibodies . Antibodies that detect CTHRC1 can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Immunocytochemistry and Immunoprecipitation. These antibodies target CTHRC1 in Human, Mouse and Rat samples. Our CTHRC1 polyclonal, … " - Cthrc1 gene

Cthrc1 gene

WebSep 23, 2024 · Through bioinformatics analyses and experiments, we confirmed that CTHRC1 is highly expressed in tissues and hepatoma cell lines. High expression of the CTHRC1 gene is associated with poor prognosis. Collectively, the results of the present study indicated that CTHRC1 may serve as a prognostic biomarker for HCC. WebGene view. The gene view histogram is a graphical view of mutations across CTHRC1. These mutations are displayed at the amino acid level across the full length of the gene …

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WebMar 20, 2024 · Correlations between CTHRC1 gene expression and clinicopathological factors were analyzed using gene expression data from UALCAN databases. Then, we searched the GEPIA database to evaluate the association of CTHRC1 gene expression with clinical outcomes. The cBioPortal database was used to analyze CTHRC1 genetic … WebApr 17, 2024 · Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. ... The Structural Features of CTHRC1. The CTHRC1 gene is located at chromosome 8q22.3, and it contains …

WebCollagen triple helix repeat containing 1 is a protein that in humans is encoded by the CTHRC1 gene. Function. This locus encodes a protein that may play a role in the … WebTreatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease Author links open overlay panel Zhaolian Bian a 1 , Qi Miao a 1 , Wei Zhong a 1 , Haiyan Zhang a , Qixia Wang a , Yanshen Peng a , Xiaoyu Chen a , Canjie Guo a , Li Shen a , Fan Yang a , Jie Xu a , Dekai Qiu a ...

WebDec 22, 2024 · The X-axis represent ligand and receptor pairs, with the first gene expressed on F13-Act-CTHRC1 cells and second gene expressed on the interacting cell types denoted in the Y-axis. Red: upregulated gene in tumor bulk RNA-seq. Blue: downregulated in tumor bulk (none present). WebFeb 8, 2024 · We assessed the cause of elevated CTHRC1 levels. DNA methylation, gene mutation, CNV was critically involved in genetic and epigenetic regulation and were …

WebAug 1, 2013 · Regulation of Cthrc1 gene expression by contact with hydroxyapatite and calcium. In order to gain further insight into the mechanism of Cthrc1 gene expression in osteoclasts, mature osteoclasts generated from BMMs ex vivo with M-CSF and RANKL were placed on different substrates, including a plastic dish, a dentin slice, or a …

WebOct 26, 2024 · The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics … slowing down global warmingWebJun 15, 2024 · Gene expression of Cthrc1 was significantly increased from day 3, peaked at day 5, and fell back at day10 after injury (Fig. 1a). To verify this result, we examined the … slowing down hair simulation blenderWebCTHRC1 is known to regulate extracellular collagen deposition and partake in vascular remodeling of arterial injury as a function of cellular response through the TGF-β and Wnt pathways. Moreover, mutation of the gene has been associated with carcinogenesis in a variety of cell and tissues, most notably esophageal adenocarcinoma and Barrett ... software mbseWebDec 1, 2001 · Disease susceptibility is associated with variants affecting the gene represented in this entry Description A condition characterized by a metaplastic … software m-bus master 250dWebMar 20, 2024 · The collagen triple helix repeat containing 1 (CTHRC1) gene is located on human chromosome 8q22.3 and was initially identified in balloon injury and normal rat … slowing down hand signalWebJul 29, 2013 · Collagen triple helix repeat containing-1 (CTHRC1) is a secreted glycoprotein that activates the planar cell polarity pathway of Wnt signaling. Using microarray analysis, we found that the CTHRC1 gene is overexpressed in hepatocellular carcinoma (HCC). The level of CTHRC1 mRNA was measured in 201 surgically resected … software mbr to gptWebJul 19, 2024 · Collagen triple helix repeat containing-1 (CTHRC1), highly expressed in multiple human solid tumors, has been identified as a tumor associated protein. … software may be used in digital sculpting