Klf2 endothelial cell

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August undefined, 2024

WebTzima et al showed that platelet and endothelial cell adhesion molecule-1 (PECAM-1, also called CD31), vascular ... showed significantly less induction of KLF2 expression than ciliated cells in the embryonic heart. 92 Primary cilia on ECs protrude into the vascular lumen and are molecular switches for Ca 2+ and NO signalling. 93 The ... WebFeb 23, 2024 · Inducible endothelial-specific deletion of Klf2 and/or Klf4 reveals that a single allele of either gene is sufficient for survival, but absence of both (EC-DKO) results …

KLF2+ stemness maintains human mesenchymal stem …

WebWe recently reported the observation that KLF2 is a potent inducer of endothelial nitric oxide synthase, a key regulator of vessel biology. 16 To gain greater insight into additional … WebIn the human body, KLFs are mainly involved in various physiological processes such as enhancing immune response, maintaining the normal function of vascular endothelium, … spa days near keswick

Role of Krüppel-Like Transcription Factors in Endothelial …

WebMay 5, 2004 · Overexpression of KLF2 in umbilical vein endothelial cells robustly induced endothelial nitric oxide synthase expression and total enzymatic activity. In addition, KLF2 overexpression potently inhibited the induction of vascular cell adhesion molecule-1 and endothelial adhesion molecule E-selectin in response to various proinflammatory cytokines. WebKLF2orchestrates vascular homeostasis and serves as a key molecular switch between proinflammatory atheroprone and quiescent atheroresistant endothelial phenotype. This characteristic is attributed to its ability to activate atheroprotective and inhibit atherogenic endothelial transcription programs. WebMar 31, 2024 · Gimbrone MA Jr, Garcia-Cardena G. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circ Res. 2016 Feb 19;118(4):620-36. doi: 10.1161/CIRCRESAHA.115.306301. spa days near lincolnshire

Kruppel-Like Factor 2 Regulates Endothelial Barrier Function

Endothelial mechanosensors in shear stress signals JIR

WebApr 9, 2013 · A new study reported in this issue of Cell Research revealed that KLF2, a transcription factor that negatively regulates endothelial functions, is also a substrate of … WebInterestingly, KLF2 inhibits endothelial cell activation by diverse proinflammatory stimuli, including interleukin (IL)-1β, tumor necrosis factor (TNF)α, lipopolysaccharide, and … spa days near me hertfordshireWebApr 30, 2024 · Expression of KLF2 by endothelial cells is known to exert protective effects against atherosclerosis, however OSS greatly reduces expression of KLF2 at both the mRNA and protein levels. To determine whether GPR30 plays a role in OSS-induced downregulation of KLF2, HAECs were exposed to OSS (± 5 dyn/cm 2 ) in the presence or absence of 5 and … spa days near horton in ribblesdale

"WebJan 24, 2024 · The role of KLF2 (Kruppel like factor 2) in ECs (endothelial cells) dysfunction and homeostasis. KLF2 is the major MSTF regulated by shear stress: down-regulated by … " - Klf2 endothelial cell

Klf2 endothelial cell

Klf2 Is an Essential Regulator of Vascular

WebLung Kruppel-like factor/KLF2 is highly expressed in the vascular endothelium (17). Systemic knockout of KLF2 results in embryonic death and abnormal vessel formation (17, 18). However, our understanding of the function and targets of KLF2 in endothelial biology have been lacking to date. We recently identiﬁed KLF2 as a novel transcriptional reg- WebFeb 5, 2024 · KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells.

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WebMay 5, 2004 · Overexpression of KLF2 in umbilical vein endothelial cells robustly induced endothelial nitric oxide synthase expression and total enzymatic activity. In addition, KLF2 … Webactivating protein-1 (AP-1) and NF-κB in human endothelial cells and VSMCs [48], probably mediated by Rho and Rac Attenuation of Inflammatory Damage proteins [49, 50]. Further study shows that statins suppress Inflammatory processes have a key role in the the activation of NF-κB probably through inducing the pathophysiology of ischemic stroke ...

WebApr 10, 2024 · Understanding the endothelial cell function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. ... endothelial miR-92a is regulated by the master EC transcription regulator KLF2, and its expression increased in arterial regions where complex hemodynamic conditions … WebApr 13, 2024 · For instance, activation of the MEK5/ERK5/KLF2 pathway by fluid shear stress in endothelial cells has recently been shown to require mROS production (Coon et al., J Cell Biol (2024) 221 (7): e202409144). By contrast, Abe’s group observed that H2O2 stimulation could enhance ERK5 phosphorylation but inhibited ERK5-mediated gene expression (e.g ...

WebFeb 14, 2013 · Krüppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal. KLF2 ablation leads to myocardial thinning, high output cardiac failure and death by mouse embryonic day 14.5 (E14.5) in a mixed genetic background. Lung buds removed from KLF2-deficient mouse embryos and cultured from normal tracheobronchial trees. In order to circumvent embryonic lethality usually observed in KLF2-deficient embryos, KLF2 homozygous null mouse embryonic stem cells were constructed and used to produce chimeric animals. These KLF2-deficient embryonic stem cells contribute significantly to development of skeletal muscle, spleen, heart, liver, kidney, stomach, brain, uterus, testis, and …

Webcultured endothelial cells, where it regulates a large number of vasoactive endothelial genes. Here, we show that Klf2 expression during development mirrors the rise of fluid shear forces, and that endothelial loss of Klf2 results in lethal embryonic heart failure due to a high-cardiac-output state.

WebMar 4, 2024 · While endothelial KLF2 and endothelium-derived KLF2-induced miRNAs have homoeostatic, anti-proliferative effect on vascular endothelial and smooth muscle cells, direct activation of KLF2 in ... teams voice for businessWebNov 13, 2024 · Krüppel-like Factor 2 (KLF2) is an important indicator of the stemness of human MSCs (hMSCs) and as early vascularization is also critical for bone regeneration, we used KLF2 as a novel in vitro marker for … spa days near me liverpoolWebMar 4, 2024 · Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. spa days near newbury