Web18. okt 2024. · In addition, TNF-α suppressed fetal hepatocyte maturation induced by oncostatin M (OSM) to promote cell cycle progression in culture 82. TNF-α is also known to prevent apoptosis and promote... WebRichards CD, Brown TJ, Shoyab M, Baumann H, Gauldie J (1992) Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro. J Immunol 148:1731–1736 Dunn JC, Tompkins RG, Yarmush ML (1991) Long-term in vitro function of adult hepatocytes in a collagen sandwich …
Human hepatocyte systems for in vitro toxicology analysis
Web26. okt 2015. · Here we describe the oncostatin M (OSM)-dependent expansion of primary human hepatocytes by low expression of the human papilloma virus (HPV) genes E6 and E7 coupled with inhibition of... Metrics - Long-term culture and expansion of primary human hepatocytes Nature Biotechnology is a monthly journal publishing new concepts in biological … Web06. dec 2024. · Human hepatocyte-like cells (HLCs) have been generated from human pluripotent stem cells by in vitro differentiation or from human somatic cells by direct transdifferentiation (Ji et al., 2013 ). This method was able to generate large numbers of functional HLCs capable of rescuing liver failure in mice after transplantation. thinkpad l450 仕様
Cancers Free Full-Text Oncostatin M: From Intracellular …
Web09. mar 2024. · The advent of human-induced pluripotent stem cells holds great promise for producing ample individualized hepatocytes. Although previous efforts have succeeded in generating hepatocytes from human pluripotent stem cells in vitro by viral-based expression of transcription factors and/or addition of growth factors during the … Web25. mar 2024. · To understand mechanisms regulating maturation of in vitro derived hepatocytes, we developed a 3D spheroid differentiation system and compared gene regulatory elements in uncultured human primary hepatocytes with those in hepatocytes that were differentiated in 2D or 3D conditions from human PSCs by RNA-seq, ATAC … Web05. jan 2015. · Here we describe a chemical biology approach for elucidating potential toxicity mechanisms for thrombosis-related side effects. This work takes advantage of a large chemical biology data set comprising the effects of known, well-characterized reference agents on the cell surface levels of tissue factor (TF) in a primary human … thinkpad l460固态硬盘