WebApr 1, 2024 · In response to cellular stresses, p53 transcriptionally activates or represses a number of downstream target genes, which, in turn, participate in the modulation of multiple biological processes including cell cycle arrest, programmed cell death, cellular senescence, DNA repair, oxidative response, and metabolic regulation ( 6 ). WebSENP1 interacts with p53 and deSUMOylates p53 in cells and in vitro. Knockdown of SENP1 markedly induced p53 transactivation activity. We further show that SENP1 depletion synergizes with DNA damage-inducing agent etoposide to induce p53 activation and the expression of p21, leading to synergistic growth inhibition of cancer cells.
An unexpected role for p53 in regulating cancer cell ... - Science
WebJul 11, 2014 · Here, we found that HRP-3 knockdown regulates the radioresistance of p53-null H1299 cells through a distinctly different molecular mechanism. HRP-3 depletion was sufficient to cause apoptosis of H1299 cells by generating substantial levels of reactive oxygen species (ROS) through inhibition of the Nrf2/HO-1 antioxidant pathway. WebFeb 20, 2012 · Knockdown of Prpf8 or UBL5 caused accumulation of p53, elevated p53-responsive transcriptional reporter activity and an increase in the mRNA and protein levels … brook hollow apartments new haven
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WebJan 1, 2016 · Results. Knockdown of the UGT1A proteins by RNAi in human colon cancer cells and knockout of the Ugt1 locus in intestinal crypt stem cells reduces phosphorylated p53 activation and compromises the ability of p53 to control apoptosis. Targeted deletion of intestinal Ugt1 expression in Ugt1 ΔIEC mice represses colon inflammation-induced p53 … WebOct 5, 2024 · Fig. 1: c-Myc activates the pan-cancer lncRNA MILIP to repress p53. a c-Myc bound to MILIP promoter in A549 and MCF-7 cells. An E-box motif, not associated with MYC target genes on Chr22, was... WebMay 25, 2007 · Introduction Morpholino phosphorodiamidate oligonucleotides (MOs) [1] and short inhibitory RNAs (siRNAs) [2] have been instrumental to induce sequence-specific … care coordination certification online