Polytheonamide
WebPolytheonamide B (1) is an ion-channel forming natural peptide with a d, l-alternating 48 amino acid sequence, which is an exceedingly potent cytotoxin.We recently designed and … WebBGC0000598: polytheonamide A biosynthetic gene cluster from Candidatus Entotheonella factor Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details.
Polytheonamide
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WebJan 1, 2013 · Polytheonamide B (1) is an ion-channel forming natural peptide with a d, l-alternating 48 amino acid sequence, which is an exceedingly potent cytotoxin.We recently … WebT1 - Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria. AU - Freeman, Michael F. AU - Vagstad, Anna L. AU - Piel, Jörn. N1 - Funding Information: We would like to thank Eike Peters for providing the ‘Entotheonella’ image depicted in Figure 3 .
WebSep 9, 2024 · The host generates polytheonamide-like compounds within 2 days, and can efficiently introduce multiple d-amino acids, asparagine N-methylations and C-methyl … WebPolytheonamide B (1) is a natural peptide that displays potent cytotoxicity against P388 mouse leukemia cells (IC 50 =0.098 n m).Linear 48-mer 1 is known to form monovalent …
WebThe β 6.3-helical channel of the marine cytotoxic peptide, polytheonamide B (pTB), is examined in water, the POPC bilayer, and a 1 : 1 chloroform/methanol mixture using all … WebA prominent example is polytheonamide A, which exhibits numerous post-translational modifications, some of which were unknown in ribosomal peptides until recently. Among these post-translational modifications, C-methylations have been proposed to be catalyzed by two putative radical S-adenosylmethionine (rSAM) enzymes, PoyB and PoyC.
WebJan 12, 2005 · Polytheonamides A and B are highly cytotoxic polypeptides with 48 amino acid residues isolated from the marine sponge, Theonella swinhoei. The structure of …
WebApr 1, 2016 · The leader sequence for the polytheonamide precursor PoyA bears homology to the alpha subunit of nitrile hydratases, yet with the conserved metal-chelating residues … can a tubeless motorcycle tire be pluggedWebFor polytheonamides, which are members of a new RiPP family termed proteusins, we have recently shown that such cleavage is catalyzed by the cysteine protease PoyH acting on … can a tulle dress be alteredWebOct 11, 2024 · The design, total synthesis, and functional analysis of a novel artificial ion channel molecule, designated as dansylated polytheonamide mimic, which exhibited potent cytotoxicity toward p388 mouse leukemia cells, effectively induced ion transport across the lipid bilayers of liposomes, and displayed H(+) and Na(+) ion channel activities. Expand can a tummy tuck cause a herniaWebAug 22, 2024 · Polytheonamide B (1) is a unique peptide natural product because of its extremely complex structure, a channel-forming ability in vitro, and the extremely potent … fish ice cooler boxWebMar 12, 2024 · Proteusins are a family of bacterial ribosomal peptides that largely remain hypothetical genome-predicted metabolites. The only known members are the polytheonamide-type cytotoxins, which have complex structures due to numerous unusual posttranslational modifications (PTMs). Cyanobacteria contain large numbers of putative … can a tumble dryer leak waterWebIn plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids fish ice bagsWebWe demonstrate the functional control of a dansylated polytheonamide mimic (2), an artificial ion channel-forming cytotoxic peptide, by the external addition of a polyclonal … can a tubeless tire be repaired